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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tocilizumab

1

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

1
Last update : 10/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Lung and liver sarcoidosis-like reaction induced by tocilizumab.
British journal of clinical pharmacology 2021 Dec;87;4848-4852 2021 Dec
Autoimmune diseases induced by biological agents. A review of 12,731 cases (BIOGEAS Registry).
Expert opinion on drug safety 2017 Nov;16;1255-1271 2017 Nov
Sarcoidosis induced by tocilizumab: a paradoxical event?
The Journal of rheumatology 2013 Oct;40;1773-4 2013 Oct

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