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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alemtuzumab

1

X.ac Anti-GBM antibody disease (Goodpasture-like or flare of preexisting GS)

1
Last update : 20/08/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Case report of anti-glomerular basement membrane disease following alemtuzumab treatment of relapsing-remitting multiple sclerosis.
Multiple sclerosis and related disorders 2013 Jan;2;60-3 2013 Jan
Anti-glomerular basement membrane disease after alemtuzumab.
The New England journal of medicine 2008 Aug 14;359;768-9 2008 Aug 14

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