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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alemtuzumab

1

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 23/08/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Alemtuzumab-induced lung injury in multiple sclerosis: Learning from adversity in three patients.
Multiple sclerosis and related disorders 2020 Jan;37;101450 2020 Jan
Acute respiratory distress syndrome following alemtuzumab therapy for relapsing multiple sclerosis.
Multiple sclerosis and related disorders 2017 May;14;1-3 2017 May
A fatal case of alemtuzumab-associated interstitial pneumonitis.
American journal of therapeutics 2008;15;82-4 2008

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