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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1
Last update : 18/02/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Bleomycin-induced lung injury treated with venovenous extracorporeal membrane oxygenation (ECMO) and ultra-protective ventilator settings.
BMJ case reports 2020 Nov 23;13; 2020 Nov 23
Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma.
Cancer 1989 Aug 15;64;806-11 1989 Aug 15
Reversible interstitial pneumonitis associated with low dose bleomycin.
Chest 1975 Aug;68;265-7 1975 Aug

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