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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

I.w Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

2
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Bleomycin-associated Lung Toxicity in Childhood Cancer Survivors.
Journal of pediatric hematology/oncology 2015 Nov;37;e447-52 2015 Nov
Lungs on fire.
BMJ case reports 2013 Jun 27;2013; 2013 Jun 27
Fatal pulmonary toxicity in testis cancer with bleomycin-containing chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Aug 10;25;3543-4 2007 Aug 10

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