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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

VI.c Pulmonary veno-occlusive disease

1
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary veno-occlusive disease after chemotherapy.
Thorax 1985 Nov;40;874-5 1985 Nov
Pulmonary veno-occlusive disease after chemotherapy with bleomycin.
Human pathology 1984 Feb;15;199 1984 Feb
Pulmonary veno-occlusive disease due to bleomycin therapy for lymphoma. Case reports.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1983 Oct 08;64;636-8 1983 Oct 08

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