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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

VI.f Hemolytic and uremic syndrome (HUS). See also under Xaf

1
Last update : 17/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy.
Cancer 1999 May 01;85;2023-32 1999 May 01
Thrombotic microangiopathy associated with chemotherapy: case report and review of the literature.
DICP : the annals of pharmacotherapy 1989;23;582-8 1989

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