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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Bleomycin
5
VI.f
Hemolytic and uremic syndrome (HUS). See also under Xaf
1
Last update :
17/04/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy.
Thrombotic microangiopathy associated with chemotherapy: case report and review of the literature.