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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Focal organizing pneumonia on surgical lung biopsy: causes, clinicoradiologic features, and outcomes.
Chest 2007 Nov;132;1579-83 2007 Nov
Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma.
Cancer 1989 Aug 15;64;806-11 1989 Aug 15
Bleomycin-induced nodular pulmonary fibrosis masquerading as metastatic testicular cancer.
The Journal of urology 1986 Aug;136;473-5 1986 Aug

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