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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Eosinophilic pneumonia associated with bleomycin in a patient with mediastinal seminoma: a case report.
Journal of medical case reports 2010 Apr 29;4;126 2010 Apr 29
Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma.
Cancer 1989 Aug 15;64;806-11 1989 Aug 15
Chemotherapy-induced eosinophilic pneumonia. Relation to bleomycin.
Chest 1985 Jul;88;103-6 1985 Jul
Bleomycin hypersensitivity pneumonitis.
Annals of internal medicine 1978 Jan;88;47-9 1978 Jan

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