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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bleomycin

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

3
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary Toxicity of Bleomycin - A Case Series from a Tertiary Care Center in Southern India.
Journal of clinical and diagnostic research : JCDR 2016 Apr;10;FR01-3 2016 Apr
Bleomycin-induced pneumonitis in three patients treated with chemotherapy for primary advanced seminoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2015;20;928-32 2015
Incidence, outcome and predictors of bleomycin pulmonary toxicity in a university hospital in Oman.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2013 Mar;19;3-7 2013 Mar
Prognostic impact of bleomycin-induced pneumonitis on the outcome of Hodgkin's lymphoma.
Annals of hematology 2011 Jan;90;67-72 2011 Jan
Bleomycin lung: a case report.
BMJ case reports 2009;2009; 2009
Diffuse ground-glass opacities in a patient with Hodgkin lymphoma and progressive respiratory failure.
Chest 2008 Jul;134;207-12 2008 Jul
Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Oct 20;23;7614-20 2005 Oct 20
Bleomycin-induced pneumonitis.
Chest 2001 Aug;120;617-24 2001 Aug
Severe bleomycin lung toxicity: reversal with high dose corticosteroids.
Thorax 1993 Jan;48;92-4 1993 Jan
Stevens-Johnson syndrome and fatal pulmonary toxicity to combination chemotherapy containing bleomycin: a case report.
Tumori 1986 Jun 30;72;331-3 1986 Jun 30
Severe bleomycin-induced pneumonitis. Clinical features and response to corticosteroids.
Chest 1984 Nov;86;723-8 1984 Nov
Pulmonary complications associated with combination chemotherapy programs containing bleomycin.
The American journal of medicine 1983 Apr;74;557-63 1983 Apr
Acute bleomycin lung.
The American review of respiratory disease 1972 Dec;106;909-13 1972 Dec

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