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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sildenafil

1

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 09/07/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
E-cigarette - E-vaporizers - ENDS - Vaping - Dabbing
5

Publications

Airway spasm or collapse? An alternate mechanism of action for an important side effect of Sildenafil warrants consideration in patients with tracheobronchomalacia.
The Journal of pediatrics 2019 Oct;213;250 2019 Oct
Sildenafil Use in Children with Pulmonary Hypertension.
The Journal of pediatrics 2019 Feb;205;29-34.e1 2019 Feb

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