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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Erlotinib

3

I.ad Radiation recall pneumonitis

1
Last update : 27/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Tyrosine kinase inhibitors (EGFR) TKI
5

Publications

Radiation recall pneumonitis caused by erlotinib after palliative definitive radiotherapy.
Onkologie 2012;35;191-4 2012
A case of radiation recall pneumonitis induced by erlotinib, which can be related to high plasma concentration.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010 Jun;5;924-5 2010 Jun

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