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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Erlotinib

3

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 09/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Tyrosine kinase inhibitors (EGFR) TKI
5

Publications

Independent review of interstitial lung disease associated with death in TRIBUTE (paclitaxel and carboplatin with or without concurrent erlotinib) in advanced non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007 Jun;2;537-43 2007 Jun

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