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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

XVII.f Tuberculosis, miliary

2
Last update : 10/05/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Pneumocystis jirovecii pneumonia in patients receiving tumor-necrosis-factor-inhibitor therapy: implications for chemoprophylaxis.
Current rheumatology reports 2014 Oct;16;445 2014 Oct
Tuberculosis and TNF-inhibitors: history of exposure should outweigh investigations.
BMJ case reports 2014 May 05;2014; 2014 May 05

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