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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

X.j Myopathy-Myositis-Polymyositis (see also under Xba)

2
Last update : 09/03/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Antitumor necrosis factor alpha inhibitor-induced dermatomyositis and interstitial lung disease with anti-PL12 autoantibody: signs of antisynthetase syndrome.
The Journal of dermatology 2014 Nov;41;1034-6 2014 Nov
New onset of dermatomyositis/polymyositis during anti-TNF-α therapies: a systematic literature review.
TheScientificWorldJournal 2014;2014;179180 2014
Dermatomyositis induced by anti-tumor necrosis factor in a patient with juvenile idiopathic arthritis.
JAMA dermatology 2013 Oct;149;1204-8 2013 Oct

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