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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

XVII.b Opportunistic pulmonary/systemic infections

3

 

 

Last update : 31/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Case 9-2020: A 64-Year-Old Man with Shortness of Breath, Cough, and Hypoxemia.
The New England journal of medicine 2020 Mar 19;382;1150-1159 2020 Mar 19
Opportunistic infections in rheumatoid arthritis patients exposed to biologic therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.
Rheumatology (Oxford, England) 2018 Jun 01;57;997-1001 2018 Jun 01
Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Hyperinfection Syndrome.
Case reports in infectious diseases 2018;2018;6341680 2018
Non-viral opportunistic infections in new users of tumour necrosis factor inhibitor therapy: results of the SAfety Assessment of Biologic ThERapy (SABER) study.
Annals of the rheumatic diseases 2014 Nov;73;1942-8 2014 Nov
Biologic therapy and risk of infection.
Skin therapy letter 2012 Apr;17;1-4 2012 Apr
Pulmonary infectious diseases in patients with primary immunodeficiency and those treated with biologic immunomodulating agents.
Current opinion in pulmonary medicine 2011 May;17;172-9 2011 May
Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective.
Current rheumatology reviews 2011 Feb;7;77-87 2011 Feb

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