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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

XVII.h Nontuberculous pulmonary mycobacterial infection/superinfection

3
Last update : 30/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

TNF inhibitors increase the risk of nontuberculous mycobacteria in patients with seropositive rheumatoid arthritis in a mycobacterium tuberculosis endemic area.
Scientific reports 2022 Mar 07;12;4003 2022 Mar 07
Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report.
BMC infectious diseases 2014 Feb 28;14;114 2014 Feb 28
Mycobacterial diseases and antitumour necrosis factor therapy in USA.
Annals of the rheumatic diseases 2013 Jan;72;37-42 2013 Jan
Rapid growing mycobacteria and TNF-α blockers: case report of a fatal lung infection with Mycobacterium abscessus in a patient treated with infliximab, and literature review.
Clinical and experimental rheumatology 2011;29;705-7 2011
Nontuberculous mycobacterial lung disease.
Current opinion in infectious diseases 2010 Apr;23;185-90 2010 Apr

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