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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

X.b Antiphospholipid antibodies w/wo the APL syndrome

1
Last update : 11/07/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Antitumor necrosis factor alpha inhibitor-induced dermatomyositis and interstitial lung disease with anti-PL12 autoantibody: signs of antisynthetase syndrome.
The Journal of dermatology 2014 Nov;41;1034-6 2014 Nov
Anti-TNF-alpha-induced anti-phospholipid syndrome manifested as necrotizing vasculitis.
Scandinavian journal of rheumatology 2010 Mar;39;175-7 2010 Mar
Autoimmune diseases induced by TNF-targeted therapies.
Best practice & research. Clinical rheumatology 2008 Oct;22;847-61 2008 Oct

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