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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
TNF-alpha antagonists / inhibitors
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Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive
1
Last update :
10/04/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Adalimumab
Etanercept
Golimumab
Infliximab
Publications
Appearance of ANCA - associated vasculitis under Tumor necrosis factor-alpha inhibitors treatment.