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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

X.d Lupus - Lupus syndrome (see also Vd)

3
Last update : 21/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Drug-specific risk and characteristics of lupus and vasculitis-like events in patients with rheumatoid arthritis treated with TNFi: results from BSRBR-RA.
RMD open 2017;3;e000314 2017
Biologics-induced autoimmune diseases.
Current opinion in rheumatology 2013 Jan;25;56-64 2013 Jan
Drug-induced lupus erythematosus: incidence, management and prevention.
Drug safety 2011 May 01;34;357-74 2011 May 01
TNF alpha antagonist-induced lupus-like syndrome: report and review of the literature with implications for treatment with alternative TNF alpha antagonists.
International journal of dermatology 2011 May;50;619-25 2011 May
Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-α antibody-treated patients with inflammatory bowel disease.
Inflammatory bowel diseases 2011 Jan;17;91-8 2011 Jan
Safety of infliximab in Crohn's disease: a large single-center experience.
Inflammatory bowel diseases 2010 Dec;16;2109-16 2010 Dec
Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey.
Arthritis research & therapy 2005;7;R545-51 2005
Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: a prospective cohort study.
Gastroenterology 2003 Jul;125;32-9 2003 Jul

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