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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

I.q Pulmonary nodulosis

3
Last update : 28/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Efficacy of rituximab on pulmonary nodulosis occurring or increasing in patients with rheumatoid arthritis during anti-TNF-α therapy.
Clinical and experimental rheumatology 2011;29;752-3 2011
Pulmonary nodulosis and aseptic granulomatous lung disease occurring in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha-blocking agent: a case series.
The Journal of rheumatology 2009 Nov;36;2421-7 2009 Nov

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