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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

X.e Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

3
Last update : 11/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Biologics-induced autoimmune diseases.
Current opinion in rheumatology 2013 Jan;25;56-64 2013 Jan
A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL-12 antibody following treatment with etanercept.
Clinical rheumatology 2011 Mar;30;429-32 2011 Mar
Autoimmune diseases induced by biological agents: a double-edged sword?
Autoimmunity reviews 2010 Jan;9;188-93 2010 Jan
Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases.
Medicine 2007 Jul;86;242-251 2007 Jul

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