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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Diverse patterns of anti-TNF-α-induced lupus: case series and review of the literature.
Clinical rheumatology 2018 Feb;37;563-568 2018 Feb
Adalimumab-induced lupus serositis.
BMJ case reports 2015 Mar 04;2015; 2015 Mar 04
Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-α.
International archives of medicine 2012 Feb 15;5;7 2012 Feb 15
Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic.
Mayo Clinic proceedings 2009 Nov;84;979-84 2009 Nov
Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases.
Medicine 2007 Jul;86;242-251 2007 Jul
Drug-induced systemic lupus erythematosus and TNF-alpha blockers.
Lancet (London, England) 2002 Aug 24;360;646 2002 Aug 24

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