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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
TNF-alpha antagonists / inhibitors
5
I.m
ILD with a granulomatous component
2
Last update :
20/01/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
Etanercept
Golimumab
Infliximab
Publications
Etanercept-induced cutaneous and pulmonary sarcoid-like granulomas resolving with adalimumab.
[TNFα blocking agents and sarcoidosis: an update].
Granulomatous lung disease occurring during etanercept treatment.
Pulmonary granulomas after tumour necrosis factor alpha antagonist therapy.
