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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lansoprazole

1

XVII.a Respiratory tract infection incl. pneumonia

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Last update : 01/05/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children.
The Journal of pediatrics 2013 Sep;163;686-91 2013 Sep
Meta-analysis: proton pump inhibitor use and the risk of community-acquired pneumonia.
Alimentary pharmacology & therapeutics 2010 Jun;31;1165-77 2010 Jun

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