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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Darbepoetin

3

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

3
Last update : 08/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Safety and efficacy of darbepoetin alpha in previously untreated extensive-stage small-cell lung cancer treated with platinum plus etoposide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 May 10;26;2342-9 2008 May 10
Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia.
JAMA 2008 Feb 27;299;914-24 2008 Feb 27

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