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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bevacizumab

3

VIII.r Tracheal/large airway necrosis, chondronecrosis, perforation

1
Last update : 01/03/2020
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pazopanib
2
Sorafenib
2
Sunitinib
2

Publications

Fatal Radiation Pneumonitis in Patients With Subclinical Interstitial Lung Disease.
Clinical lung cancer 2018 Jul;19;e417-e420 2018 Jul

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