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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bevacizumab

3

III.h Major/massive hemoptysis

1
Last update : 22/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pazopanib
2
Sorafenib
2
Sunitinib
2

Publications

Bevacizumab for non-small-cell lung cancer: A nested case control study of risk factors for hemoptysis.
Cancer science 2016 Dec;107;1837-1842 2016 Dec
Bronchoscopic findings for bevacizumab-related pulmonary hemorrhage in advanced non-small cell lung cancer.
Investigational new drugs 2013 Oct;31;1364-6 2013 Oct
Increased risk of serious hemorrhage with bevacizumab in cancer patients: a meta-analysis.
Oncology 2010;79;27-38 2010
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Oct 20;25;4743-50 2007 Oct 20
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.
The New England journal of medicine 2006 Dec 14;355;2542-50 2006 Dec 14
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004 Jun 01;22;2184-91 2004 Jun 01

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