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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bevacizumab

3

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

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Last update : 14/08/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pazopanib
2
Sorafenib
2
Sunitinib
2

Publications

Diffuse alveolar hemorrhage as a fatal adverse effect of bevacizumab: an autopsy case.
Japanese journal of clinical oncology 2014 May;44;497-500 2014 May
Diffuse alveolar haemorrhage may be associated with intravitreal injection of bevacizumab in a patient with systemic risk factors.
BMJ case reports 2011 Feb 02;2011; 2011 Feb 02

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