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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bevacizumab

3

VIII.o Perforation of the nasal septum

1
Last update : 04/12/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Pazopanib
2
Sorafenib
2
Sunitinib
2

Publications

An observational study of nasal cavity toxicity in cancer patients treated with bevacizumab.
Expert opinion on drug safety 2014 Nov;13;1437-42 2014 Nov
[Perforation of the nasal septum: a rare complication of bevacizumab].
Revue des maladies respiratoires 2012 Nov;29;1124-6 2012 Nov

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