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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

XVII.e Pneumocystis jiroveci pneumonia

1
Last update : 22/02/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

A Case of Pneumonia under Belatacept and Everolimus: Benefit-Risk Balance between Renal Allograft Function and Infection.
Case reports in nephrology and dialysis 2021;11;10-15 2021
Pneumonia and Acute Kidney Injury Induced by Everolimus Treatment in a Patient with Metastatic Breast Cancer.
Case reports in oncology 2020;13;170-175 2020
Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study.
The European respiratory journal 2015 Sep;46;783-94 2015 Sep
Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer.
Medical mycology case reports 2014 Oct;6;34-6 2014 Oct
Pneumocystis jirovecii pneumonia under everolimus in two patients with metastatic pancreatic neuroendocrine tumors.
Investigational new drugs 2014 Dec;32;1308-10 2014 Dec
A case of pneumocystis pneumonia associated with everolimus therapy for renal cell carcinoma.
Japanese journal of clinical oncology 2013 May;43;559-62 2013 May

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