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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 06/07/2012
 
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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See also under
MTOR inhibitors
5

Publications

Lingual angioedema associated with everolimus.
Acta oncologica (Stockholm, Sweden) 2010;49;107-9 2010
[67-year-old patient with speech disorder and dysphagia].
Deutsche medizinische Wochenschrift (1946) 2008 Nov;133;2463-4 2008 Nov
Recommendations for the use of everolimus (Certican) in heart transplantation: results from the second German-Austrian Certican Consensus Conference.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Apr;26;305-11 2007 Apr
Immunosuppressive therapy with everolimus can be associated with potentially life-threatening lingual angioedema.
Transplantation 2005 Apr 27;79;981-3 2005 Apr 27

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