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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

I.l Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

Patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma.
Japanese journal of clinical oncology 2012 May;42;442-6 2012 May
Sirolimus-induced pneumonitis complicated by pentamidine-induced phospholipidosis in a renal transplant recipient: a case report.
Transplantation proceedings 2011 Sep;43;2792-7 2011 Sep

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