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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 07/03/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

A Fatal Case of Life-Threatening Interstitial Pneumonitis Induced by Everolimus for Metastatic Renal Cell Carcinoma: A Comment about the Increased Risk of Interstitial Lung Disease in Japanese.
Case reports in urology 2019;2019;2703871 2019
Everolimus induced pneumonitis in a lung transplant recipient.
Oxford medical case reports 2018 Apr;2018;omy008 2018 Apr
Complications of Lung Transplantation: A Roentgenographic Perspective.
Chest 2016 Jun;149;1535-45 2016 Jun
Fatal acute pulmonary injury associated with everolimus.
The Annals of pharmacotherapy 2012 Mar;46;e7 2012 Mar
Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma.
American journal of respiratory and critical care medicine 2010 Aug 01;182;396-403 2010 Aug 01
Everolimus-associated pneumonitis in 3 heart transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009 Jan;28;104-6 2009 Jan
Severe everolimus-associated pneumonitis in a renal transplant recipient.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Oct;23;3353-5 2008 Oct

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