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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dasatinib

4

XII.c Pericardial effusion (w/wo tamponade)

3
Last update : 17/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bosutinib
2
Imatinib
3
Ponatinib
2

Publications

Lupus-like symptoms with anti-RNP/Sm and anti-nuclear antibodies positivity: An extremely rare adverse event of dasatinib.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2020 Apr;26;738-741 2020 Apr
Incidence, risk factors and management of pleural effusions during dasatinib treatment in unselected elderly patients with chronic myelogenous leukaemia.
Hematological oncology 2013 Jun;31;103-9 2013 Jun
Occurrence and current management of side effects in chronic myeloid leukemia patients treated frontline with tyrosine kinase inhibitors.
Leukemia research 2013 Jun;37;713-20 2013 Jun
Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily.
Haematologica 2011 Jan;96;163-6 2011 Jan
Pleural/pericardic effusions during dasatinib treatment: incidence, management and risk factors associated to their development.
Expert opinion on drug safety 2010 Sep;9;713-21 2010 Sep
Serosal inflammation (pleural and pericardial effusions) related to tyrosine kinase inhibitors.
Targeted oncology 2009 Apr;4;99-105 2009 Apr

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