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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cetuximab

4

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 13/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Incidence and risk factors of interstitial lung disease of patients with head and neck cancer treated with cetuximab.
Head & neck 2019 Aug;41;2574-2580 2019 Aug
Cetuximab-associated pulmonary toxicity in concurrent chemoradiation for the treatment of a squamous cell carcinoma of the head and neck.
Head & neck 2019 Apr;41;E55-E58 2019 Apr
A case of fatal cetuximab-induced interstitial lung disease during the first weeks of treatment.
Targeted oncology 2014 Jun;9;177-80 2014 Jun
Cetuximab monotherapy in patients with advanced non-small cell lung cancer after prior epidermal growth factor receptor tyrosine kinase inhibitor therapy.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010 Nov;5;1855-8 2010 Nov
Acute interstitial pneumonitis in a patient receiving a FOLFOX-4 regimen plus cetuximab treated with pulse therapy.
International journal of clinical pharmacology and therapeutics 2010 Jul;48;425-8 2010 Jul

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