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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cetuximab

4

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

3
Last update : 14/05/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy-naive advanced non-small cell lung cancer.
The Cochrane database of systematic reviews 2014 Nov 17;2014;CD009948 2014 Nov 17
Incidence of cetuximab-related infusion reactions in oncology patients treated at the University of North Carolina Cancer Hospital.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2014 Dec;20;409-16 2014 Dec
Cetuximab hypersensitivity infusion reactions: Incidence and risk factors.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2013 Sep;19;222-7 2013 Sep
Systematic review on infusion reactions associated with chemotherapies and monoclonal antibodies for metastatic colorectal cancer.
Current clinical pharmacology 2012 Feb 01;7;56-65 2012 Feb 01
Escitalopram--translating molecular properties into clinical benefit: reviewing the evidence in major depression.
Journal of psychopharmacology (Oxford, England) 2010 Aug;24;1143-52 2010 Aug
High incidence of cetuximab-related infusion reactions in Tennessee and North Carolina and the association with atopic history.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Aug 20;25;3644-8 2007 Aug 20

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