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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Paracetamol - Acetaminophen

3

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 22/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007⁻2018.
Pharmacy (Basel, Switzerland) 2019 Jan 17;7; 2019 Jan 17
Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.
Allergy 2013 Jul;68;929-37 2013 Jul
Selective anaphylaxis to paracetamol in a child.
European annals of allergy and clinical immunology 2012 Aug;44;163-6 2012 Aug
Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1996 Dec;77;473-4 1996 Dec

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