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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bortezomib

2

XII.a Left or biventricular dysfunction/failure

1
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

[Bortezomib-associated acute congestive heart failure in a patient with multiple myeloma].
[Rinsho ketsueki] The Japanese journal of clinical hematology 2015 Jan;56;44-7 2015 Jan
Severe heart failure after bortezomib treatment in a patient with multiple myeloma: a case report and review of the literature.
Acta haematologica 2012;128;244-7 2012
Bortezomib-induced Severe Congestive Heart Failure.
Cardiology research 2010 Dec;1;20-23 2010 Dec
Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report.
BMC cancer 2006 May 11;6;129 2006 May 11

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