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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bortezomib

2

II.b ARDS - Acute lung injury

2
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Rapid fatal pulmonary complications in a Chinese patient after bortezomib treatment for ALK-negative anaplastic large-cell lymphoma.
Clinical lymphoma, myeloma & leukemia 2010 Apr;10;152-4 2010 Apr
[Pulmonary toxicity after bortezomib].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2008;32;301-2 2008
Development of fatal bortezomib induced acute lung injury despite concurrent therapy with high-dose dexamethasone.
Leukemia & lymphoma 2007 Jan;48;212-3 2007 Jan
Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma.
Blood 2006 May 01;107;3492-4 2006 May 01
Severe pulmonary complications in African-American patient after bortezomib therapy.
American journal of therapeutics 2006;13;553-5 2006

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