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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bortezomib

2

X.n Tumor lysis syndrome (TLS)

1
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Tumor lysis syndrome early after treatment with bortezomib for multiple myeloma.
Pharmacotherapy 2006 Aug;26;1205-6; discussion 1206 2006 Aug
Tumor lysis syndrome after bortezomib therapy for plasma cell leukemia.
Pharmacotherapy 2005 Dec;25;1820-5 2005 Dec
Tumour lysis syndrome in multiple myeloma after bortezomib (VELCADE) administration.
Journal of cancer research and clinical oncology 2004 Oct;130;623-5 2004 Oct

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