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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Bortezomib
2
X.n
Tumor lysis syndrome (TLS)
1
Last update :
09/07/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Tumor lysis syndrome early after treatment with bortezomib for multiple myeloma.
Tumor lysis syndrome after bortezomib therapy for plasma cell leukemia.
Tumour lysis syndrome in multiple myeloma after bortezomib (VELCADE) administration.