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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Oxaliplatin-based regimens
4
I.a
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
1
Last update :
11/07/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
FOLFOX chemotherapy regimen
Fluorouracil (5-FU)
Oxaliplatin
Publications
Oxaliplatin-induced Pulmonary Toxicity: A Rare but Serious Complication.
Interstitial lung disease caused by oxaliplatin. An uncommon but not unknown complication.
Fatal pneumonitis induced by oxaliplatin: description of three cases.