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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Temozolomide

2

XVII.e Pneumocystis jiroveci pneumonia

2
Last update : 16/08/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pneumocystis jirovecii pneumonia prophylaxis during temozolomide treatment for high-grade gliomas.
Critical reviews in oncology/hematology 2013 Mar;85;373-82 2013 Mar
Fatal pneumonia associated with temozolomide therapy in patients with malignant glioma.
Japanese journal of clinical oncology 2012 Jul;42;632-6 2012 Jul
Patients receiving standard-dose temozolomide therapy are at risk of Pneumocystis carinii pneumonia.
Clinical oncology (Royal College of Radiologists (Great Britain)) 2007 Oct;19;631-2 2007 Oct

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