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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Phenazopyridine

2

XIV.b Sulfhemoglobinemia

1
Last update : 11/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A 36-Year-Old Woman With Intermittent Cyanosis.
Chest 2024 Aug;166;e29-e33 2024 Aug
Sulfhemoglobinemia in a 53-Year-Old With a History of Phenazopyridine Misuse.
Cureus 2023 Jun;15;e40944 2023 Jun
Acrocyanosis from phenazopyridine-induced sulfhemoglobinemia mistaken for Raynaud phenomenon.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2009 Apr;15;127-9 2009 Apr
Phenazopyridine-induced sulfhemoglobinemia.
The Annals of pharmacotherapy 2005 Jun;39;1128-30 2005 Jun
Phenazopyridine-induced sulfhemoglobinemia: inadvertent rechallenge.
The American journal of medicine 1991 Sep;91;315-7 1991 Sep

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