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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Adalimumab

3

XVII.g Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

1
Last update : 30/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
TNF-alpha antagonists / inhibitors
5

Publications

Adalimumab-Receiving Ulcerative Colitis Patient Suffered Latent Tuberculosis Reactivation Despite Correct Chemoprophylaxis and was Successfully Treated while on Anti-Tumour Necrosis Factor Therapy.
Journal of Crohn's & colitis 2016 Dec;10;1453-1454 2016 Dec
Tuberculosis of the tongue in a patient with rheumatoid arthritis treated with methotrexate and adalimumab.
Le infezioni in medicina 2014 Jun;22;144-8 2014 Jun
Reactivation of latent tuberculosis in a Crohn's patient after TB prophylaxis treated with adalimumab.
The American journal of gastroenterology 2013 Jul;108;1181-2 2013 Jul
Multiple organ tuberculosis of lung, pleura, and peritoneum in ankylosing spondylitis during adalimumab therapy.
Rheumatology international 2012 Mar;32;787-90 2012 Mar
Tuberculous monoarthritis after treatment with adalimumab in Crohn's disease.
Revista espanola de enfermedades digestivas 2012 Mar;104;157-8 2012 Mar
Oral tuberculosis in a patient with rheumatoid arthritis after long treatment with methotrexate and adalimumab.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2010 Oct;16;330-1 2010 Oct
Tuberculous myositis in a patient with ankylosing spondylitis treated with adalimumab.
Rheumatology international 2009 Sep;29;1381-4 2009 Sep

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