Pneumotox » Drug » Adalimumab » I.a - Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Adalimumab

ILD cases that occurred with combo treatments (methotrexate + adalimumab) (e.g. PMID 24626274) are not included due un uncertain causality

Last update : 17/03/2014

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment