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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Adalimumab

3

XVII.e Pneumocystis jiroveci pneumonia

1
Last update : 06/04/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
TNF-alpha antagonists / inhibitors
5

Publications

Pneumocystosis in a patient with Crohn's disease treated with combination therapy with adalimumab.
Journal of Crohn's & colitis 2012 May;6;483-7 2012 May
Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of the first 3,000 patients.
Modern rheumatology 2012 Aug;22;498-508 2012 Aug
[Pneumocystis pneumonia developed in two patients with rheumatoid arthritis during treatment of adalimumab].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2011;34;420-5 2011
Pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab.
Scandinavian journal of infectious diseases 2007;39;475-8 2007

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