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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Adalimumab

3

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
TNF-alpha antagonists / inhibitors
5

Publications

Chronic cough and an atypical pattern of peripheral pulmonary opacities: A case report secondary to suspected drug onset.
The Journal of asthma : official journal of the Association for the Care of Asthma 2018 Jan;55;106-110 2018 Jan
Asthma-like symptoms in a patient with rheumatoid arthritis and Adalimumab treatment.
Pneumologia (Bucharest, Romania) 2015;64;28-30 2015
Asthma unmasked with tumor necrosis factor-α-blocking drugs.
Chest 2011 Oct;140;1068-1071 2011 Oct
Bronchospasm associated with anti-TNF treatment.
Clinical rheumatology 2009 Aug;28;989-92 2009 Aug
Adalimumab-induced bronchospasm: not a class effect.
Thorax 2008 May;63;472-3 2008 May

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