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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Epoprostenol

3

II.a Pulmonary edema, noncardiogenic (NCPE)

3
Last update : 30/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Prostacyclin
3
Prostaglandins
1

Publications

A Man with Severe Pulmonary Hypertension and Right Ventricular Failure.
Annals of the American Thoracic Society 2018 Dec;15;1472-1476 2018 Dec
Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial.
Annals of internal medicine 2000 Mar 21;132;425-34 2000 Mar 21
Pulmonary edema complicating prostacyclin therapy in pulmonary hypertension associated with scleroderma: a case of pulmonary capillary hemangiomatosis.
Arthritis and rheumatism 2000 Mar;43;699-703 2000 Mar
Short-term and long-term epoprostenol (prostacyclin) therapy in pulmonary hypertension secondary to connective tissue diseases: results of a pilot study.
The European respiratory journal 1999 Jun;13;1351-6 1999 Jun
Pulmonary edema complicating continuous intravenous prostacyclin in pulmonary capillary hemangiomatosis.
American journal of respiratory and critical care medicine 1998 May;157;1681-5 1998 May

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