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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gold (chrysotherapy)

3

IV.c Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

1
Last update : 17/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Aurothiopropanosulfonate
3

Publications

Bronchiolar disease associated with gold compounds administration in a patient with rheumatoid arthritis.
Modern rheumatology 2005;15;148-52 2005
Constrictive bronchiolitis obliterans following gold therapy for psoriatic arthritis.
The European respiratory journal 1995 Dec;8;2191-3 1995 Dec
Intravenous cyclophosphamide and methylprednisolone for the treatment of bronchiolitis obliterans and interstitial fibrosis associated with crysotherapy.
The Journal of rheumatology 1988;15;850-4 1988
Bronchiolitis in a rheumatoid arthritis patient receiving auranofin.
Arthritis and rheumatism 1986 Apr;29;556-9 1986 Apr
Fatal bronchiolitis obliterans associated with chrysotherapy.
Annals of the rheumatic diseases 1983 Oct;42;593-6 1983 Oct

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